The FIVE Institute is a 5-MeO-DMT training and research organization preparing facilitators, therapists, clinicians, and researchers to work safely and ethically with this molecule.
A 9-month professional certification that prepares
experienced practitioners to support the 5-MeO-DMT
experience safely and ethically, taught by more than 30
clinicians, therapists, scientists, and legacy facilitators.
An interdisciplinary faculty of 30+ clinicians, scientists, therapists, legacy facilitators, and educators contributing original research, clinical expertise, and applied training methodology to The FIVE Institute, upholding rigorous standards of evidence and care.
Recognized globally as the most comprehensive 5-MeO-DMT training and faculty available in the field.
View the Faculty Directory →
Book a free 30-minute discovery call to learn more.
The FIVE Institute is guided by a vision in which the full therapeutic and scientific potential of 5-MeO-DMT is responsibly realized. We are committed to advancing evidence-based approaches that deepen understanding of this molecule, combining the expertise of leading researchers, clinicians and legacy practitioners with the latest advances in science.
Our work spans both naturalistic and clinical research, conducted in partnership with institutional collaborators including Imperial College London and UCL, and extends to advisory support for clinical and pharmaceutical development. Data and real-world evidence drive new training methods, educational content, protocols, and product development pathways.
Awake rat neuroimaging maps dose- and sex-dependent effects of 5-MeO-DMT on functional brain connectivity across cortical and subcortical regions.
A phase 2a open-label trial found a single intranasal dose of 5-MeO-DMT was well tolerated alongside stable SSRI use, with promising early reductions in depressive symptoms.
EEG recordings from 29 healthy adults show that high-dose inhaled 5-MeO-DMT reorganizes cortical slow-wave activity into a more stable, low-dimensional state.
Naturalistic EEG and phenomenological interviews reveal 5-MeO-DMT can induce a state of "deconstructed consciousness," marked by reduced alpha and beta brain activity.
With Dr. Robin Carhart-Harris, Dr. Manesh Girn, and Tommaso Barba
Our panel discusses what current research is revealing about how 5-MeO-DMT may affect the brain differently from other psychedelics such as N,N-DMT, psilocybin, and LSD.
With Hamilton Morris
World renowned psychedelic researcher and TV personality Hamilton Morris discusses the common misconceptions that are prevalent around 5-MeO-DMT.
With Dr. Malin Uthaug
Field researcher Dr. Malin Vedoy Uthaug explores what her research is revealing about transformation through the lens of physiology, regulation, and the body's capacity to adapt.
With Dr. Christopher Timmermann
An in-depth exploration with Dr. Chris Timmermann of 5-MeO-DMT, ego dissolution, neuroscience, meditation, and the scientific study of consciousness.
Self-guided courses accessible to anyone, providing the foundational knowledge needed to understand 5-MeO-DMT.
