Research on The FIVE Institute

Non-Hallucinogenic 5-MeO-DMT: Can You Separate Neuroplasticity From the Psychedelic Experience?

Fri, 02 Oct 2026 00:00:00 -0700

In The FIVE Institute’s recent seminar, neuroscientists Manesh Girn, PhD and Lindsay Cameron, PhD joined The FIVE Institute Co-Founder Joel Brierre for a conversation about an emerging area of psychedelic science: non-hallucinogenic neuroplastogens.

The discussion centered on a simple question: Can some of the biological effects associated with psychedelics be separated from the psychedelic experience itself?

Brain Entropy and 5-MeO-DMT

Fri, 10 Jul 2026 00:00:00 -0700

In The FIVE Institute’s recent webinar, Brain Entropy and 5-MeO-DMT, neuroscientist Manesh Girn, PhD moderated a conversation with Dr. Robin Carhart-Harris and Tommaso Barba, PhD(c) on one of the most fascinating questions in psychedelic science: what happens in the brain during the profound states of consciousness associated with 5-MeO-DMT?

What 5-MeO-DMT Can Teach Us About Consciousness

Fri, 10 Jul 2026 00:00:00 -0700

In The FIVE Institute’s webinar, Dr. Chris Timmermann joined Joel Brierre and Victoria Wueschner for a deeper conversation on 5-MeO-DMT, DMT, meditation, and the scientific study of consciousness.

Dr. Timmermann is the co-director of the UCL Center for Consciousness Research, where his work explores how psychedelics and meditation can help us better understand the relationship between mind, brain, and human experience. He has helped pioneer some of the first investigations into how DMT and 5-MeO-DMT act in the brain, with a particular focus on neuroscience, phenomenology, ethics, and consciousness research.

How 5-MeO-DMT Fits Into the Future of Psychedelic Therapy

Mon, 29 Sep 2025 00:00:00 -0700

Here’s the FDA giving 5-MeO-DMT its first green light for Phase 2b trials. The “God molecule” is officially entering mainstream medicine.

You’re probably thinking, “Wait, wasn’t this just something people talked about in hushed tones at conferences?” And honestly? You’re not wrong to feel a bit overwhelmed. This field’s moving fast, and it’s hard to know what’s real progress versus what’s just hype.

5-MeO-DMT for PTSD and Mental Disorders

Tue, 25 Jul 2023 00:00:00 -0700

In the realm of mental health, the search for effective treatments for conditions like Post-Traumatic Stress Disorder (PTSD), depression, and anxiety is a never-ending journey. As our understanding of these mental disorders deepens, so does our exploration of potential remedies. One such promising candidate is 5-MeO-DMT, a fast-acting psychedelic derived from the Bufo alvarius toad.