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5-MeO-DMT Research Program

5-MeO-DMT Research
Real-World Impact.

In collaboration with leading academic and research institutions,
The FIVE Institute contributes naturalistic, clinical, and real-world
evidence that informs robust, evidence-based standards of care.
Partner With Us →Contact Our Team →

Reviewed by The FIVE Institute · Last reviewed

Disclaimer: 5-MeO-DMT is a Schedule I controlled substance in the United States and is regulated in many jurisdictions. This page is educational and does not condone or encourage its use.

In research partnership with
Imperial College LondonUniversity College LondonThe University of UtahMINDSUniversité de MontréalQualia Research Institute
Why Research Matters

How Research Drives Us Forward

Real-world evidence that informs safer, more effective care.

At the heart of our mission lies a commitment to advancing the understanding of 5-MeO-DMT through rigorous research. Real-time evidence collected at our Tepoztlán institute allows us to refine and improve our educational programs, ensuring they are grounded in the latest insights and best practices. We believe that research is essential not only for safety and efficacy but for expanding the understanding and accessibility of 5-MeO-DMT in therapeutic settings.
Explore Our Training →View Bibliography →
A researcher fitting an EEG cap on a study participant
A study participant wearing a high-density EEG cap
A researcher preparing EEG electrodes before a recording session
The Science

Why 5-MeO-DMT Research Matters

01020304EVIDENCE · 04 STAGESFINDINGS FEED BACK INTO PRACTICEREAL-WORLD DATA2,500+ participant outcomesfrom medically supervised retreats.STUDIESNaturalistic and clinical researchwith academic partners.PUBLICATIONSPeer-reviewed findings sharedwith the wider field.STANDARDS OF CAREEvidence built into training,protocols and screening.
Fig. 2 · From Real-World Evidence to Standards of Care

Bridging Knowledge Gaps

5-MeO-DMT offers a unique window into consciousness. By altering functional brain connectivity (Cavallaro et al., 2026), it allows researchers to study how self-awareness is constructed and how the brain processes non-ordinary states (Timmermann et al., 2025).

Therapeutic Discovery

Early studies suggest 5-MeO-DMT may support meaningful change in just one or a few sessions alongside therapy, with emerging evidence in depression, PTSD, and anxiety (Davis et al., 2019; Ragnhildstveit et al., 2023; Seynaeve et al., 2026).
5-MeO-DMT Research

Research Partnerships

Partner With Us → View All Studies →
We proudly collaborate with world-leading institutions, bringing together pioneering minds to unlock new applications for 5-MeO-DMT. These partnerships enrich our work, offering invaluable expertise and resources that help propel the field forward. Together, we are committed to setting a high standard for psychedelic research, ensuring it is both ethically sound and scientifically robust.
The FIVE Institute Research Partners
Imperial College LondonUniversity College London (opens in a new tab)The University of Utah (opens in a new tab)MINDSUniversité de MontréalQualia Research Institute (opens in a new tab)

Latest in 5-MeO-DMT Research

View All Studies →
Aug 2025Cell Reports · 44(8)

Complex slow waves in the human brain under 5-MeO-DMT

EEG recordings from 29 healthy adults show that high-dose inhaled 5-MeO-DMT reorganizes cortical slow-wave activity into a more stable, low-dimensional state.

G. Blackburne · R. McAlpine · 5 more
Jan 2025Cell Reports · 44(8)

The void and the brain

A commentary on Blackburne et al.'s EEG findings, noting profoundly slowed brain activity under high-dose 5-MeO-DMT without the alpha-power reduction typical of other psychedelics.

Koch, C.
1 / 8
From Evidence to Practice

How Research Informs Our Training

Our educational offerings are directly shaped by ongoing research, allowing us to provide students and healthcare professionals with up-to-date protocols and safety standards. Each insight gathered from our studies becomes a building block in training practitioners to work confidently with 5-MeO-DMT, bridging the gap between theoretical knowledge and hands-on application.
Explore Our Training →
5-MeO-DMT vaporization devices set out during a FIVE Institute training session
A facilitator sitting with a group of trainees during a FIVE Institute training
Work With Us

Ways to Collaborate

Choose the partnership that fits your institution or organization.

Research Partnerships

Collaborate with our team on naturalistic and clinical studies of 5-MeO-DMT.
Propose a research partnership →

Clinical & Pharmaceutical Advisory

Advisory support for clinical trials, pharmaceutical development, and regulatory policy.
Request advisory support →

Education Partnerships

Bring evidence-based 5-MeO-DMT harm reduction education to your institution or organization.
Discuss an education partnership →
Upcoming Studies

Join the Study Waitlist

Be the first to hear when new 5-MeO-DMT
research studies are open to participants.

We periodically recruit participants for naturalistic and clinical research. Join the waitlist and our research team will contact you when a study you may be eligible for opens.
What happens next

Our research team reviews each sign-up and contacts you by email when a study that matches your profile opens.

Your information stays private

Your details are used only to contact you about research opportunities and are never sold or shared outside our research team.

Questions about a study?

Reach our research team directly at info@five-meo.education.

Need support right now?

This waitlist is not monitored around the clock. For free, confidential peer support after a psychedelic experience, contact the Fireside Project at 62-FIRESIDE (623-473-7433), 11am to 11pm PT daily. In an emergency, call 911 or your local emergency number.

Find a 5-MeO-DMT Integration Specialist →

Eligibility is determined separately for each study, and joining the waitlist does not enroll you in a study. We use your information only to contact you about research opportunities. See our Privacy Policy.

Questions & Answers

Frequently Asked Questions

What research does The FIVE Institute conduct?
The FIVE Institute conducts and contributes to naturalistic and clinical research on 5-MeO-DMT in collaboration with academic and research institutions, including EEG research published in Cell Reports (Blackburne et al., 2025). Browse the full 5-MeO-DMT bibliography in the research field.
Does The FIVE Institute support clinical trials?
Yes. The FIVE Institute supports clinical trials such as the state-funded clinical trial authorized by Utah House Bill 390 at the University of Utah’s Huntsman Mental Health Institute, which includes 5-MeO-DMT for veterans with treatment-resistant PTSD (University of Utah Health, 2026).
Who conducts research at The FIVE Institute?
Our faculty and advisory team includes clinical psychologists, a neuroscientist, a neuropharmacologist, and a pharmacologist, working alongside experienced 5-MeO-DMT practitioners. The FIVE Institute also conducts research with academic institutions.
How does research shape your training?
Findings from current research inform the protocols and safety standards taught in our 5-MeO-DMT Facilitator Training and the guidance in our Harm Reduction Hub.
How can my institution collaborate with The FIVE Institute?
We work with institutions on research partnerships, clinical and pharmaceutical advisory, and education partnerships. See Ways to Collaborate or contact the research team.
Can I take part in a study?
Join the study waitlist and our research team will contact you when a study you may be eligible for opens. If you need support after a 5-MeO-DMT experience, visit our Integration Support page.