5-MeO-DMT LIVE Seminars

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Live 5-MeO-DMT seminars on science, safety,
ethics, and facilitation, with audience Q&A
and a growing library of free recordings.

Reviewed by The FIVE Institute · Last reviewed

Disclaimer: Information shared by seminar speakers does not necessarily represent the views of The FIVE Institute, and The FIVE Institute is not responsible for inaccurate information shared by guest speakers. 5-MeO-DMT is a Schedule I controlled substance in the United States and is regulated in many jurisdictions. These recordings are educational and do not condone or encourage its use.

Latest Seminar Recording

5-MeO-DMT for the Scientific Study of Consciousness

With Dr. Christopher TimmermannCo-Director, UCL Centre for Consciousness Research

An in-depth exploration with Dr. Chris Timmermann of 5-MeO-DMT, ego dissolution, neuroscience, meditation, and the scientific study of consciousness.

What you'll learn
  • Why consciousness is central to the study of psychedelics
  • How 5-MeO-DMT differs from DMT in subjective experience and brain activity
  • Ego dissolution, "pure awareness" and the "everything and nothing" state, and what they reveal about the sense of self
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Live sessions include audience Q&A with the speakers. Dates are announced to the email list first.

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The Seminar Archive

Free recordings of every FIVE 5-MeO-DMT seminar, from neuroscience and consciousness research to safety, harm reduction, psychotherapy and integration, taught by the field’s leading researchers, clinicians and facilitators.

Common Misconceptions of 5-MeO-DMT

RecordingMisconceptions & Education

Common Misconceptions of 5-MeO-DMT

Hamilton Morris

Common Misconceptions / Psychedelic Education

What you'll learn
  • Why the evidence for ancient, ancestral use of Bufo alvarius secretion is far shakier than often claimed, and where the stronger archaeological record actually points
  • How 5-MeO-DMT behaves differently from other tryptamines, including amnesia, loss of awareness and anesthetic-like effects
  • What the "dreaded underdose" is and why lower doses are not automatically gentler
  • Simple safety steps that prevent common harms, such as fasting beforehand to avoid vomiting while unconscious
  • Why the toad secretion is essentially just 5-MeO-DMT, and what that means for the synthetic-versus-toad debate
  • Live Q&A on dosing, set and setting, and emerging EEG and EKG research
Panel: Brain Entropy and 5-MeO-DMT seminar

RecordingComparative Neuroscience

Panel: Brain Entropy and 5-MeO-DMT

Dr. Robin Carhart-Harris, Dr. Manesh Girn & Tommaso Barba

Brain Entropy / Comparative Psychedelics

What you'll learn
  • Why 5-MeO-DMT is associated with profound self-dissolution rather than vivid visual imagery
  • How EEG research is beginning to map 5-MeO-DMT's effects on brain rhythms, including slow-wave, alpha and theta activity
  • Why brain entropy may be better understood as a marker of expanded consciousness than simply "richness" of experience
  • The roles of the serotonin 1A and 2A receptors
  • Nondual states, meditation research and neuroplasticity
  • Therapeutic mechanisms and the clinical potential of 5-MeO-DMT
5-MeO-DMT for the Scientific Study of Consciousness

RecordingConsciousness Research

5-MeO-DMT for the Scientific Study of Consciousness

Dr. Christopher Timmermann

Ego Dissolution / Neuroscience & Meditation

What you'll learn
  • Why consciousness is central to the study of psychedelics
  • How 5-MeO-DMT differs from DMT in subjective experience and brain activity
  • Ego dissolution, "pure awareness" and the "everything and nothing" state, and what they reveal about the sense of self
  • How psychedelic experiences may involve processes of deconstruction and reconstruction
  • Why low-dose 5-MeO-DMT may overlap with non-dual meditation states
  • What brain entropy and EEG research are beginning to show
Non-Hallucinogenic 5-MeO-DMT: Neuroplasticity, Brain Repair & Psychedelic Medicine seminar

RecordingDrug Development

Non-Hallucinogenic 5-MeO-DMT: Neuroplasticity, Brain Repair & Psychedelic Medicine

Dr. Manesh Girn, Dr. Lindsay Cameron & Joel Brierre

Neuroplastogens / Drug Development

What you'll learn
  • What neuroplastogens are, and whether plasticity can be separated from the psychedelic experience
  • The roles of the serotonin 5-HT2A and 5-HT1A receptors
  • The debate over what "non-hallucinogenic" really means
  • The drug-development landscape for psychedelic-inspired medicines
  • Emerging research on brain repair, and why the experience itself may still matter
Bodyset, Pivotal Physical States, & Catharsis of 5-MeO-DMT seminar

RecordingPhysiology & Somatics

Pivotal States, & Catharsis of 5-MeO-DMT

Dr. Malin Uthaug

Bodyset & Physiology / Catharsis & Regulation

What you'll learn
  • Bodyset, the state of the body, and why it matters as much as mindset
  • Catharsis: when release is healing, and when it is a nervous-system red flag
  • Pivotal Physical States (PiPS): extreme or transitional physiological conditions that can lead to healing or trauma depending on adaptability and regulation
  • What practitioners, facilitators and serious seekers should understand about integration as a bodily process
UCL X FIVE: Research Recap From the World's First 5-MeO-DMT EEG Study seminar

RecordingResearch Study

UCL X FIVE: Research Recap From the World's First 5-MeO-DMT EEG Study

James W. Sanders, George Blackburne & Dr. Rosalind McAlpine

EEG Research / Consciousness / UCL X FIVE

What you'll learn
  • How 5-MeO-DMT uniquely reorganizes brain activity compared to sleep, anesthesia, and classical psychedelics
  • Key EEG findings showing paradoxical wakefulness and low-frequency brain dynamics
  • What microphenomenology reveals about stages of deconstruction, "everything and nothing," and no-report states
  • Why 5-MeO-DMT may function as a research model for minimal or contentless consciousness
5-MeO-DMT, Toad Medicine & The Ego Trip seminar

RecordingCulture & Ecology

5-MeO-DMT, Toad Medicine & The Ego Trip

Kimon de Greef

Bufo Alvarius / Ethics & Ecology

What you'll learn
  • How the modern "toad medicine" movement rose, including the influence of Octavio Rettig
  • Questions surrounding claims of ancestral Indigenous use
  • Psychedelic tourism in Sonora and the economics of collecting toad secretions
  • The ecological and human costs of harvesting Sonoran Desert toads
  • The pharmaceutical race to develop synthetic 5-MeO-DMT
5-MeO-DMT vs. N,N-DMT seminar

RecordingComparative Psychedelics

5-MeO-DMT vs. N,N-DMT

Dr. Andrew Gallimore & Rak Razam

N,N-DMT / Neuroscience

What you'll learn
  • Why N,N-DMT and 5-MeO-DMT feel so different despite their similar names
  • What EEG data shows about 5-MeO-DMT, the default mode network and the sense of self
  • Organized versus desynchronized brain activity, and why the brain balances both
  • How receptor genetics may explain why people respond differently
  • Harm reduction: contraindications, working with a competent facilitator and knowing your source
5-MeO-DMT: Benefits, Risks, Safety & Getting Started (DoubleBlind x F.I.V.E.) seminar

RecordingHarm Reduction

5-MeO-DMT: Benefits, Risks, Safety & Getting Started (DoubleBlind x F.I.V.E.)

Mary Carreon, Joel Brierre & Victoria Wueschner

Harm Reduction / Getting Started

What you'll learn
  • What 5-MeO-DMT is and how it differs from DMT, psilocybin and LSD
  • Potential benefits, risks and contraindications, and why it should not be approached casually or alone
  • The rise of vape pens and the harm-reduction concerns they raise
  • Why integration after 5-MeO-DMT differs from other psychedelics
  • The ethical and ecological case for synthetic 5-MeO-DMT
  • What to look for when vetting facilitators, retreats or training programs
Trauma & 5-MeO-DMT: Considerations for Safety seminar

RecordingTrauma & Safety

Trauma & 5-MeO-DMT: Considerations for Safety

Dr. Bianca Sebben

Trauma / Dissociation

What you'll learn
  • How developmental and other trauma can surface during 5-MeO-DMT experiences
  • Screening tools for dissociation, such as the Dissociative Experiences Scale
  • Consent when working with dissociation and parts of the self
  • Why eyes-closed inward work or breathwork can be contraindicated for some people
  • What a safe container means: when it starts, when it ends and what happens if integration support is not enough
The Future of 5-MeO-DMT: Numinus x F.I.V.E. seminar

RecordingClinical Research & Training

The Future of 5-MeO-DMT: Numinus x F.I.V.E.

Payton Nyquvest, Dr. Paul Thielking, Hannah Cross, Joel Brierre & Victoria Wueschner

Clinical Research / Practitioner Training

What you'll learn
  • Why 5-MeO-DMT is a focus of drug development right now, and what early clinical data is showing
  • Risks and adverse events seen in clinical trials
  • Why trained, two-person support matters, including seizure-like movement and injury risk
  • Medical and transformational models of 5-MeO-DMT work, and how they differ
  • Preparation for existential fears, and the integration and ethics the field needs next
Combining Ibogaine & 5-MeO-DMT: Safety Considerations seminar

RecordingSafety & Clinical Practice

Combining Ibogaine & 5-MeO-DMT: Safety Considerations

Dr. Deborah C. Mash & Laura Shapiro

Ibogaine / Screening & Safety

What you'll learn
  • Why ibogaine has surged in popularity and why 5-MeO-DMT is now often added after it
  • Ibogaine-specific screening: cardiac risk, psychiatric review and clinical phenotyping
  • Why combining the two can destabilize people who are not prepared, and what crisis support is seeing
  • Where regulation is heading, and why clinical trials would study ibogaine on its own
  • What responsible practice requires before, during and after a combined protocol
5-MeO-DMT & the Death Experience seminar

RecordingPhenomenology

5-MeO-DMT & the Death Experience

Dr. Pascal Michael

Near-Death Experiences / Ego Dissolution / Non-Dual States

What you'll learn
  • Core similarities between 5-MeO-DMT experiences and near-death experiences
  • Which features of NDEs are not reliably reproduced by 5-MeO-DMT
  • The role of ego dissolution, oneness, and time-space transcendence in both states
  • Why dualistic elements (entities, life review, other worlds) differ across experiences
Exploring the Therapeutic Potential of 5-MeO-DMT: Psychotherapy, Preparation & Integration seminar

RecordingPsychotherapy & Integration

Exploring the Therapeutic Potential of 5-MeO-DMT: Psychotherapy, Preparation & Integration

Dustin Kerrone & Roger Kaufman

Psychotherapy / Integration

What you'll learn
  • How 5-MeO-DMT experiences can influence the therapeutic process, and why each person responds differently
  • Reparative experiences and finding presence within adversity
  • Attunement: why being met, rather than analyzed, is healing
  • Integrating "in real time" during long sub-peak phases
  • Low-dose and full-dose work, and the facilitator's own felt safety when holding space
Boosting Neuroplasticity seminar

RecordingNeuroscience

Boosting Neuroplasticity

Dr. Manesh Girn

Neuroplasticity / Neuroscience

What you'll learn
  • What neuroplasticity actually is, from neurons and dendrites to synapses
  • How the prefrontal cortex and hippocampus relate to emotional regulation and escaping rumination
  • The roles of the serotonin 2A and 1A receptors in flexibility and learning
  • What animal research shows, and how far it applies to 5-MeO-DMT
  • Why plasticity is becoming a major theme in medicine and behavioral care
5-MeO-DMT, Psychedelics & Psychosis seminar

RecordingSafety & Neurobiology

5-MeO-DMT, Psychedelics & Psychosis

Haley Maria Dourron

Safety / Neurobiology / Reactivations

What you'll learn
  • Why 5-MeO-DMT is pharmacologically and phenomenologically distinct from classical psychedelics
  • What "reactivations" are, how they differ from HPPD, and why terminology matters
  • Evidence linking 5-HT1A-dominant activity to seizure-like and dissociative phenomena
  • How route of administration, dosing patterns, and metabolism may influence risk
5-MeO-DMT: Ethics & Facilitation (Presentation and Q&A) seminar

RecordingEthics & Facilitation

5-MeO-DMT: Ethics & Facilitation (Presentation and Q&A)

Dr. Rick Barnett & Roger Kaufman

Ethics / Facilitation / Harm Reduction

What you'll learn
  • Why 5-MeO-DMT requires fundamentally different facilitation skills than other psychedelics
  • How trauma, psychological disorders, and motivation impact participant safety
  • The risks of under-training, overconfidence, and one-size-fits-all dosing
  • Why personal experience, supervision, and community accountability are essential
  • Why fear and hesitation around facilitation can be a sign of ethical maturity
  • How to evaluate readiness, motivation, and "beginner's impulse" in facilitators
  • The risks of low-dose pens, titration models, and insufficient lived experience
  • Ethical considerations around toad conservation, synthetic use, and informed consent
Vape Pen Ethics & Safety Summit seminar

RecordingHarm Reduction

Vape Pen Ethics & Safety Summit

Rak Razam, Chad Charles, Joel Brierre, Victoria Wueschner & Connie Magee

Vape Pens / Harm Reduction / Informed Consent

What you'll learn
  • Why vape pens fundamentally change the risk profile and responsibility of 5-MeO-DMT
  • How low-dose pens can still lead to overwhelming, destabilizing, or dangerous experiences
  • The ethical gaps created by commodification, misleading marketing, and lack of warnings
  • Why preparation, integration, and stewardship are essential, even outside ceremony
5-MeO-DMT Facilitation Training Q&A with Joel Brierre and Victoria Wueschner

RecordingEthics & Facilitation

5-MeO-DMT Facilitation Training Q&A

Joel Brierre & Victoria Wueschner

Facilitation / Training

What you'll learn
  • Why it matters to check your "why" before stepping into a facilitator role, and the "beginner's impulse" to serve too soon
  • What a facilitator training can teach, and the skill sets (like psychotherapy or IFS) it cannot replace
  • Why mentors and community accountability are essential for seeing your blind spots
  • Whether facilitating Bufo alvarius and synthetic 5-MeO-DMT differs, and the ethical case for synthetic
  • Why licensed clinicians still need personal experience, and the unlearning many therapeutic paradigms require
  • The risks of serving with vape pens without full-release experience, and why short trainings fall short
  • Managing participants' expectations rather than chasing a particular "deep" experience
The Unique Integration Process of 5-MeO seminar

RecordingIntegration

The Unique Integration Process of 5-MeO

Otto Maier, Sara Snedeker & James W. Sanders

Integration / Somatics / Reactivations

What you'll learn
  • Why 5-MeO-DMT integration differs fundamentally from other psychedelics
  • How somatic reverberations, reactivations, and vulnerability commonly show up post-experience
  • The difference between challenging experiences and traumatic outcomes
  • Why preparation, pacing, and post-experience spaciousness are essential for safety
Healing Identity-Based Trauma With 5-MeO-DMT seminar

RecordingTrauma & Integration

Healing Identity-Based Trauma With 5-MeO-DMT

Tony Pham, Charlotte James & Jonathan "Quest" Brown

Identity-Based Trauma / Integration / Facilitation Ethics

What you'll learn
  • How identity-based trauma shapes the nervous system, psyche, and sense of belonging
  • Why spiritual bypassing ("we're all one") can deepen harm rather than heal it
  • The role of ancestry, lineage, and lived experience in psychedelic integration
  • How facilitation ethics, power dynamics, and cultural context affect safety and outcomes
Facilitator Training

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