Making A Difference



As the psychedelic renaissance is well underway, 5-MeO-DMT is becoming more popular than ever. As the Bufo Alvarius toad naturally produces 5-MeO-DMT along with a dozen other tryptamine and alkaloids, it has become a target from human beings.

The toad population is being decimated and now runs the risk of becoming endangered. It is our responsibility as a community to preserve and protect these creatures and find other more sustainable solutions.

Learn how the Bufo Alvarius toads are being affected, best toad handling practices, solutions to ensure their safety and the importance of knowing your source. 


Threat #1


As a result of both a lack of awareness and integrity, the toads are being largely displaced. Human beings are entering the Bufo Alvarius toads’ natural habitat, collecting them to harvest the medicine and then leaving them far away from their original location. As these toads never travel further than 50 meters from their homes, they endlessly try to find their way home and are often killed in the process.

Threat #2


Due to the rise in popularity of using the Bufo Alvarius venom for 5-MeO-DMT, human beings are entering their natural habitat to milk the toads without using any gloves. This has caused a new fungus called Chytrid Fungus to spread amongst the toads. Gloves must be worn at all times during collection practices and changed after each toad.

Threat #3


More and more human beings uneducated in ethical milking practices are taking it upon themselves to milk the Bufo Alvarius secretion. Due to the lack of awareness, people are over-milking the toads and, as a result, are leaving the toad population defenseless against their prey. This has caused an increase in their mortality rate. When milking, only the first 2 paranoidal glands should be milked and no more than every 4-6 weeks.

Threat #4


As the desire for the Bufo Alvarius secretion grows, so does extractive capitalism. Certain individuals and groups have decided to monetize the sacred Bufo Alvarius secretion and, as a result, they are engaging in unethical practices to get the most amount of financial return possible. 

Threat #5


As the popularity of obtaining Bufo Alvarius secretion is rising, a shocking number of individuals are taking the toads out of their natural habitats to live a life of captivity. For obvious reasons this is highly unethical. Toads should always be kept in their original location in their native habitat.

Threat #6


As human beings pursue the potent Bufo Alvarius secretion, a lack of safe and ethical practices are leaving the toads with extensive physical damage. To make matters worse, excessive milking practices are causing infections, resulting in both blood and pus in the secretion itself. 



The Bufo Alvarius toad and its medicine are sacred gifts. In honor of these gifts, we have developed this document to share techniques for handling toads more safely and respectfully. WBAC does not condone the handling or milking of the Bufo Alvarius, but we acknowledge that people are engaging in this practice, and if this is being done, it should be done in a way that is safe and sustainable for the toads themselves.

The practice of milking toad glands for the purpose

of obtaining secretions for use in spiritual or ceremonial practices should also be done in accordance with protocols established by

existing guardians of the land, including any tribal protocols and in accordance with state and/or federal jurisdiction and regulations regarding amphibian handling. If you plan to handle toads, please consider doing so in a sacred manner and take precautions to protect the toads from unnecessary harm. And remember–the toads only come up to eat and breed, if you engage them too early in the season you could break that cycle.

Captive/pet toads cannot survive in the wild.

There is a high risk that captive toads can spread diseases (like amphibian chytrid fungus) to wild populations. In addition, captive toads cannot survive being released into the wild in where they are unfamiliar with conditions and predators. It is considered inhumane to release them where they pose a significant danger to the wild populations.

Drive carefully in toad territory

Toads are attracted to vehicle headlights and many get run over and die on roads. If you can’t avoid driving through toad breeding territory, drive slowly, use headlights and have someone scan the road in front of you while you drive. Check under and around tires before driving away from a site. If you spot a toad on the road, drive around it or carefully move it to the side of the road.

Leave adult toads exactly where you find them

Adult toads cannot survive being moved to a new location. Toads will become disoriented and are unable to hide from predators in an unfamiliar place. They will likely die in an unfamiliar location (even if the new place is good toad habitat) or in the attempt to return to their original breeding site. Toads have strong fidelity to their first breeding site and will continue to return to the same place for the rest of their lives. Furthermore, moving toads disrupts their ability to breed, lay eggs and reproduce the next generation.

Handling toads cause stress

A toad’s body will only release secretions when they are under stress. Handling or milking their glands causes stress and should be acknowledged. While amphibians do not show visible external signs of stress, internal hormones may be surging, which have a negative effect on the immune system of the toad. Milking also depletes the toad’s immune and defense systems and it can take 30-60 days for it to fully recover. During the recovery period, the toad’s immune and defense systems are impaired, are more vulnerable to predators and illness, and have less energy available for breeding. Handling Bufo Alvarius toads does not transmit warts or disease to humans, but you could be spreading amphibian chytrid fungus from an infected toad to other toads.


The Sonoran desert toad has large paratoid glands on both sides of the back of its head and smaller glands on its hind legs. Milking all the glands on a single toad leaves it defenseless. Consider milking only one or a portion of the glands. Don’t milk all the toads at a single site, and give toads plenty of time to recover before visiting the site again. This may require developing an agreement or system with other people who visit the same sites.

Minimize handling stress

Keep handling time to a minimum. If it is necessary to place a toad in a holding container, even temporarily, be sure that the container has first been disinfected. Do not place multiple toads together in a container, as this increases the chance of injury and spread of infectious disease. Place a lid with sufficient air holes and a dark, visual barrier over the top of the holding container as the sight of a predator (human) causes fear and induces an internal stress response in amphibians. Disinfect holding containers between uses and between sites.

Reduce the spread of infectious toad diseases

Amphibian chytrid fungus is a serious disease worldwide and has been detected in some Sonoran Desert toad populations. The greatest risk of contamination happens when toads are placed in contact with each other, in the same container, or in reused holding containers that have not been disinfected. To protect toads from the spread of this disease, wear disposable gloves when handling toads and disinfect your hands before and after touching the animals. If you are visiting more than one breeding site (each individual water body should be considered a separate site), be sure to change your gloves and disinfect hands, containers, and any equipment that come into contact with toads or water (including muddy boots or tires) before visiting a new site. Remember not to move toads from one site to another and never release captive toads into the wild.

Disinfect your equipment

Clean equipment, containers, boots or anything that comes into contact with wild toads, muddy soil, or water in a toad breeding habitat to ensure you are not passing on any fungi.

  1. 1)  Wear clean, disposable gloves or wash hands with hand sanitizer containing at least 70% ethanol or for at least 1 minute

  2. 2)  Spray containers and equipment with 70% ethanol or 1% bleach solution for at least 1 minute

  3. 3)  Wash clothing and cloth bags in hot water at 60°C or higher

  4. 4)  Dry containers and equipment completely for 4 hours at 37°C

  5. 5)  Rinse muddy boots and tires and dry completely for 4 hours at 37°C

This field protocol has been developed based on the best available scientific evidence regarding amphibian hygiene and handling from herpetologists we have consulted with. This is a working document that will be updated as new and better data becomes available.

"An Ethical Solution"



There has been a debate in the community of whether the Bufo Alvarius secretion and The Pure Molecule, also known as Jaguar or Synthetic, are the same in experiential nature. While both compounds take users to the same space, ego attachment can cling to the idea of natural being the “right” or “better” way. This is not necessarily true.

We are at a time in humanity where nature is asking us to expand our minds and accept new possibilities by working together for a more sustainable future. Here are some reasons why switching to The Pure Molecule can be a more sustainable and ethical option for both toads and human beings:

The Experience of both Synthetic & Toad are the same.

Synthetic is actually safer as the additional tryptamines and alkaloids possess cardio toxic material, putting humans at risk of heart failure.

Synthetic is safer for dosage specificity as the Bufo Alvarius secretion contains anywhere from 10-29% 5-MeO-DMT, leaving a very large margin for error in dosing, opening to risks such as serotonin syndrome.